1,4-Dioxane hydrochloride → 6-(6-Bromo-benzotriazol-1-ylmethyl)-imidazo[1,2-b]pyridazin-2-ylamine Hydrochloride

HRID 1925117Notes

Reaction equation

HRID 1925117 reaction equation
C(OC(=O)[NH:7][C:8]1[N:9]=[C:10]2[CH:15]=[CH:14][C:13]([CH2:16][N:17]3[C:21]4[CH:22]=[C:23]([Br:26])[CH:24]=[CH:25][C:20]=4[N:19]=[N:18]3)=[N:12][N:11]2[CH:27]=1)(C)(C)C.[ClH:29].O1CCOCC1>>[ClH:29].[Br:26][C:23]1[CH:24]=[CH:25][C:20]2[N:19]=[N:18][N:17]([CH2:16][C:13]3[CH:14]=[CH:15][C:10]4[N:11]([CH:27]=[C:8]([NH2:7])[N:9]=4)[N:12]=3)[C:21]=2[CH:22]=1

Participants

3

Reactant 2

HCID 204431481,4-Dioxane hydrochlorideHCID 59233266[6-(6-Bromo-benzotriazol-1-ylmethyl)-imidazo[1,2-b]pyridazin-2-yl]-carbamic acid tert-butyl ester

Product 1

HCID 666334826-(6-Bromo-benzotriazol-1-ylmethyl)-imidazo[1,2-b]pyridazin-2-ylamine Hydrochloride

Procedure

A solution of compound 10H (0.44 g, 1.0 mmol) in 4N HCl/dioxane (10 mL) was stirred at room temperature for 60 minutes, concentrated and dried in vacuum to give 0.3 g of product (10) as a hydrochloride salt. ESI-MS:m/z 344.1 (M+H)+.

Workup

  1. concentrationconcentrated
  2. customdried in vacuum

Sources & evidence

ORD record
ord-d9fd5eeaad59488181714d179833e1b3
Source dataset
uspto-grants-2012_05
Patent number
US08178534B2

Reaction notes

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