HCID 59232978, compound → HCID 59233273, compound

HRID 1925143Notes

Reaction equation

HRID 1925143 reaction equation
[Br:1][C:2]1[CH:3]=[CH:4][C:5]2[N:6]([C:8]([C:11]([F:30])([F:29])[C:12]3[CH:13]=[CH:14][C:15]4[N:16]([CH:18]=[C:19]([NH:21]C(=O)OC(C)(C)C)[N:20]=4)[N:17]=3)=[N:9][N:10]=2)[CH:7]=1>Cl.O1CCOCC1>[Br:1][C:2]1[CH:3]=[CH:4][C:5]2[N:6]([C:8]([C:11]([F:29])([F:30])[C:12]3[CH:13]=[CH:14][C:15]4[N:16]([CH:18]=[C:19]([NH2:21])[N:20]=4)[N:17]=3)=[N:9][N:10]=2)[CH:7]=1

Participants

3

Reactant 1

HCID 59232978HCID 59232978, compound

Product 1

HCID 59233273HCID 59233273, compoundYield 100.2%

Reagents, catalysts & solvents 1

HCID 204431481,4-Dioxane hydrochlorideSolvent

Procedure

A solution of tert-butyl 6-((6-bromo-[1,2,4]triazolo[4,3-a]pyridin-3-yl)difluoromethyl)imidazo[1,2-b]pyridazin-2-ylcarbamate (2.8 g, 5.83 mmol) in 4N HCl/dioxane (25 mL) was stirred at ambient temperature for 1 hr. The solvent was removed via rotary evaporation and the residue was dried under vacuum to provide the title compound, 6-((6-Bromo-[1,2,4]triazolo[4,3-a]pyridin-3-yl)difluoromethyl)imidazo[1,2-b]pyridazin-2-amine 45M (2.2 g, 5.84 mmol, 92%), as HCl salt. This material was used without further purification. ESI-MS:m/z 380.1 (M+H)+.

Workup

  1. customThe solvent was removed via rotary evaporation
  2. customthe residue was dried under vacuum

Sources & evidence

ORD record
ord-a2b4e7108f4d4e4bad5ebf0e5cb9ab5b
Source dataset
uspto-grants-2012_05
Patent number
US08178534B2

Reaction notes

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