HCID 59232978, compound → HCID 59233273, compound

Participants

Reaction Steps

A solution of tert-butyl 6-((6-bromo-[1,2,4]triazolo[4,3-a]pyridin-3-yl)difluoromethyl)imidazo[1,2-b]pyridazin-2-ylcarbamate (2.8 g, 5.83 mmol) in 4N HCl/dioxane (25 mL) was stirred at ambient temperature for 1 hr. The solvent was removed via rotary evaporation and the residue was dried under vacuum to provide the title compound, 6-((6-Bromo-[1,2,4]triazolo[4,3-a]pyridin-3-yl)difluoromethyl)imidazo[1,2-b]pyridazin-2-amine 45M (2.2 g, 5.84 mmol, 92%), as HCl salt. This material was used without further purification. ESI-MS:m/z 380.1 (M+H)+.

Provenance & Evidence