2-Hydrazinopyridine → HCID 59233223, compound

HRID 1925158Notes

Reaction equation

Br[C:2]1[CH:3]=[CH:4][C:5]2[N:6]([C:8]([CH:11]([C:13]3[CH:14]=[CH:15][C:16]4[N:17]([CH:19]=[C:20]([NH:22][C:23]([CH:25]5[CH2:27][CH2:26]5)=[O:24])[N:21]=4)[N:18]=3)[CH3:12])=[N:9][N:10]=2)[CH:7]=1.N(C1C=CC=CN=1)N>>[N:10]1[N:9]=[C:8]([CH:11]([C:13]2[CH:14]=[CH:15][C:16]3[N:17]([CH:19]=[C:20]([NH:22][C:23]([CH:25]4[CH2:27][CH2:26]4)=[O:24])[N:21]=3)[N:18]=2)[CH3:12])[N:6]2[CH:7]=[CH:2][CH:3]=[CH:4][C:5]=12

Participants

Reactant 2

HCID 786452-Hydrazinopyridine

HCID 59233190HCID 59233190, compound

Product 1

HCID 59233223HCID 59233223, compound

Procedure

The title compound was synthesized using an analogous procedure to that described in the preparation of Compound 48 (Method A) using 2-hydrazinylpyridine. 1H NMR (400 MHz, DMSO-d6) δ ppm 0.73-0.87 (m, 4 H) 1.83-1.99 (m, 4 H) 5.04-5.15 (m, 1 H) 6.94-7.04 (m, 1 H) 7.19 (d, J=9.35 Hz, 1 H) 7.38-7.47 (m, 1 H) 7.80 (d, J=9.35 Hz, 1 H) 7.94 (d, J=9.85 Hz, 1 H) 8.10 (s, 1 H) 8.35 (d, J=7.07 Hz, 1 H) 11.14 (s, 1 H). MS:m/z 348.2 (M+H)+.

Sources & evidence

ORD record: ord-0c6aec362b154cb2918b9bf3b9351db7
Source dataset: uspto-grants-2012_05
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US08178534B2

Reaction notes

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