反应详情

The crude product obtained in step A) is dissolved in a mixture of methanol and tetra-hydrofuran (1:1). Then 3.5 mol equivalents of potassium hydroxide are added at room temperature and the mixture is stirred for 1 hour. Then water is added and the mixture is washed with n-hexane. The aqueous layer is then acidified by addition of KHSO4 and extracted with chloroform. The combined extracts are washed with water and brine, dried (Na2SO4) and concentrated to obtain the desired title compound.

1. washthe mixture is washed with n-hexane
2. additionThe aqueous layer is then acidified by addition of KHSO4
3. extractionextracted with chloroform
4. washThe combined extracts are washed with water and brine
5. dry with materialdried (Na2SO4)
6. concentrationconcentrated