P-Anisidine → 2-((4-Methoxy-phenylamino)-methylene)-malonic acid diethyl ester

HRID 1925285Notes

Reaction equation

HRID 1925285 reaction equation
[CH3:1][O:2][C:3]1[CH:9]=[CH:8][C:6]([NH2:7])=[CH:5][CH:4]=1.CO[CH:12]=[C:13]([C:19]([O:21][CH2:22][CH3:23])=[O:20])[C:14]([O:16][CH2:17][CH3:18])=[O:15]>>[CH3:1][O:2][C:3]1[CH:9]=[CH:8][C:6]([NH:7][CH:12]=[C:13]([C:14]([O:16][CH2:17][CH3:18])=[O:15])[C:19]([O:21][CH2:22][CH3:23])=[O:20])=[CH:5][CH:4]=1

Participants

3

Reactant 2

HCID 7732P-AnisidineHCID 3016162Diethyl methoxymethylenemalonate

Product 1

HCID 6189812-((4-Methoxy-phenylamino)-methylene)-malonic acid diethyl ester

Conditions

Temperature
100 °C

Procedure

In a flask maintained under reduce pressure, p-methoxyaniline (35.1 g, 280 mmol) and diethyl 2-(methoxymethylene)malonate (73.97 g, 340 mmol) were stirred at 100° C. for two h. The crude mixture was used without further purification.

Workup

  1. temperatureIn a flask maintained
  2. customThe crude mixture was used without further purification

Sources & evidence

ORD record
ord-005deeca3c1b44e79a1908868992c54f
Source dataset
uspto-grants-2012_05
Patent number
US08178557B2

Reaction notes

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