HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 1925285Generated: October 28, 2026
P-Anisidine → 2-((4-Methoxy-phenylamino)-methylene)-malonic acid diethyl ester
https://huagongshe.com/reaction/1925285
Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | P-Anisidine | HCID 7732 | — |
| Reactant | Diethyl methoxymethylenemalonate | HCID 3016162 | — |
| Product | 2-((4-Methoxy-phenylamino)-methylene)-malonic acid diethyl ester | HCID 618981 | — |
Reaction Steps
In a flask maintained under reduce pressure, p-methoxyaniline (35.1 g, 280 mmol) and diethyl 2-(methoxymethylene)malonate (73.97 g, 340 mmol) were stirred at 100° C. for two h. The crude mixture was used without further purification.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
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| Patent number | US08178557B2 |
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| Source dataset | uspto-grants-2012_05 |
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| ORD ID | ord-005deeca3c1b44e79a1908868992c54f |
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| Source note | uspto-grants-2012_05 |
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