HCID 3522175, compound → 2-(4-Aminophenyl)-1-(4-methylpiperazin-1-yl)ethan-1-one

HRID 1925387Notes

Reaction equation

HRID 1925387 reaction equation
[CH3:1][N:2]1[CH2:7][CH2:6][N:5]([C:8](=[O:19])[CH2:9][C:10]2[CH:15]=[CH:14][C:13]([N+:16]([O-])=O)=[CH:12][CH:11]=2)[CH2:4][CH2:3]1.[H][H]>CCO.[Pd]>[CH3:1][N:2]1[CH2:3][CH2:4][N:5]([C:8]([CH2:9][C:10]2[CH:15]=[CH:14][C:13]([NH2:16])=[CH:12][CH:11]=2)=[O:19])[CH2:6][CH2:7]1

Participants

5

Reactant 2

HCID 3522175HCID 3522175, compoundHCID 178418361HCID 178418361, compound

Product 1

HCID 167730792-(4-Aminophenyl)-1-(4-methylpiperazin-1-yl)ethan-1-one

Reagents, catalysts & solvents 2

HCID 23938PalladiumCatalystHCID 702EthanolSolvent

Procedure

A solution of 1-methyl-4-[(4-nitrophenyl)acetyl]piperazine (1.5 g, 5.70 mmol) in EtOH (30 mL) was reduced over palladium/charcoal (10% wt, 50% wet, 150 mg) with hydrogen under atmospheric pressure and RT for 18 h. The catalyst was separated by filtration through Celite® and the solvent evaporated to the title compound as a brown oil, 1.12 g.

Workup

  1. customThe catalyst was separated by filtration through Celite®
  2. customthe solvent evaporated to the title compound as a brown oil, 1.12 g

Sources & evidence

ORD record
ord-d76bb9487ff64392b6800777ef0332fb
Source dataset
uspto-grants-2012_05
Patent number
US08178557B2

Reaction notes

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