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HRID1925398

反应详情

EQUATION

反应方程式

HRID 1925398 的结构方程式

REACTANTS

反应物

3
结构：Nc1ccccn1
HCID10439

2-Aminopyridine

C5H6N2

结构：CCN(C(C)C)C(C)C
HCID81531

Diisopropylethylamine

C8H19N

结构：COc1ccc(C(=O)Cl)cc1[N+](=O)[O-]
HCID12375463

4-Methoxy-3-nitrobenzoyl chloride

C8H6ClNO4

PRODUCTS

生成物

1
结构：COc1ccc(C(=O)Nc2ccccn2)cc1[N+](=O)[O-]
HCID718006

未命名化合物

AUXILIARIES

试剂、催化剂与溶剂

1
结构：ClCCl
溶剂HCID6344

Dichloromethane

CH2Cl2

PROCEDURE

实验过程

4-methoxy-3-nitrobenzoyl chloride (1.08 g, 0.005 mol), 2-aminopyridine (0.94 g, 0.01 mol) and DIPEA (1.8 mL, 0.01 mol) were allowed to stir in DCM (10 mL) for 48 h to form 4-methoxy-3-nitro-N-(pyridin-2-yl)benzamide. Intermediate was purified via silica column chromatography using 0 to 100% EtOAc in hexane.