反应详情

Saturated hydrogen chloride in diethyl ether (15 mL) was added to a solution of (R)-1-(3,4-methylenedioxyphenyl)-2-propylaminopentane (8.00 g) in diethyl ether (80 mL) under ice-cooling and stirring. The precipitated crystals were collected by filtration and washed four times with diethyl ether (1 mL). The resulting powder (7.44 g) was dissolved by heating in acetone (150 mL), and the solution was concentrated to about 100 mL. The solution was allowed to stand at 5° C. for 15 hours. The precipitated crystals were collected by filtration and washed three times with acetone (5 mL) to give (R)-1-(3,4-methylenedioxyphenyl)-2-propylaminopentane hydrochloride (4.58 g, 24% yield).

1. temperaturecooling
2. filtrationThe precipitated crystals were collected by filtration
3. washwashed four times with diethyl ether (1 mL)
4. dissolutionThe resulting powder (7.44 g) was dissolved
5. temperatureby heating in acetone (150 mL)
6. concentrationthe solution was concentrated to about 100 mL
7. filtrationThe precipitated crystals were collected by filtration
8. washwashed three times with acetone (5 mL)