反应详情

To a solution of Intermediate 26 (0.32 g, 0.56 mmol) in a mixture of methanol (5 mL) and tetrahydrofuran (5 mL) was added palladium on charcoal (10%, 0.03 g). The reaction mixture was hydrogenated at 40 psi for 3 days. The catalyst was filtered through Celite® and the solvent removed under reduced pressure. The crude was purified by chromatography eluting with chloroform/methanol (6:1) to give the title compound as a solid (0.102 g, 37%)

1. filtrationThe catalyst was filtered through Celite®
2. customthe solvent removed under reduced pressure
3. customThe crude was purified by chromatography
4. washeluting with chloroform/methanol (6:1)