反应详情

To a solution of Intermediate 30 (7 g, 17.5 mmol) in dioxane (70 mL) was added hydrogen chloride (1.25M in dioxane, 25 mL). The reaction mixture was stirred at room temperature overnight. The precipitate was filtrated and washed with dioxane and ether. The crude was purified by column chromatography with silica gel, eluting with methylen chloride/methanol/ammonium (40:4:0.2) and the title compound was obtained as an oil (2.6 g, 50%). (M+): 300.

1. filtrationThe precipitate was filtrated
2. washwashed with dioxane and ether
3. customThe crude was purified by column chromatography with silica gel
4. washeluting with methylen chloride/methanol/ammonium (40:4:0.2)