反应详情

温度

45 °C

To a solution of Intermediate 32 (0.48 g, 0.68 mmol) in tetrahydrofuran (12 mL) was added tetrabutylammonium fluoride trihydrate (0.284 g, 1.09 mmol). The reaction mixture was stirred at 45° C. for 3.5 hours. The solvent was removed under reduced pressure and the crude was partitioned between ethyl acetate and water. The organic layer was washed several times with water and the solvent was removed under reduced pressure to give the title compound as a yellow solid (0.375 g, 88%). MS (M+): 593.

1. customThe solvent was removed under reduced pressure
2. customthe crude was partitioned between ethyl acetate and water
3. washThe organic layer was washed several times with water
4. customthe solvent was removed under reduced pressure