HCID 67520709, compound → HCID 42623781, compound

HRID 1925507Notes

Reaction equation

HRID 1925507 reaction equation
[C:1]12([CH2:11][O:12][C:13]3[CH:18]=[CH:17][C:16]([CH2:19][CH2:20][NH:21][CH2:22][C@@H:23]([C:25]4[CH:34]=[CH:33][C:32]([O:35]CC5C=CC=CC=5)=[C:31]5[C:26]=4[CH:27]=[CH:28][C:29](=[O:43])[NH:30]5)[OH:24])=[CH:15][CH:14]=3)[CH2:10][CH:5]3[CH2:6][CH:7]([CH2:9][CH:3]([CH2:4]3)[CH2:2]1)[CH2:8]2>[Pd]>[C:1]12([CH2:11][O:12][C:13]3[CH:18]=[CH:17][C:16]([CH2:19][CH2:20][NH:21][CH2:22][C@@H:23]([C:25]4[CH:34]=[CH:33][C:32]([OH:35])=[C:31]5[C:26]=4[CH:27]=[CH:28][C:29](=[O:43])[NH:30]5)[OH:24])=[CH:15][CH:14]=3)[CH2:10][CH:5]3[CH2:4][CH:3]([CH2:9][CH:7]([CH2:6]3)[CH2:8]1)[CH2:2]2

Participants

3

Reactant 1

HCID 67520709HCID 67520709, compound

Product 1

HCID 42623781HCID 42623781, compoundYield 69%

Reagents, catalysts & solvents 1

HCID 23938PalladiumCatalyst

Procedure

Obtained from Intermediate 38 (0.17 g, 0.32 mmol) and palladium on charcoal (10%, 0.034 g) by the same procedure described in Example 1 (reaction time: 2 days). The crude obtained was triturated with ether and filtrated to obtain the title compound as a yellow solid (0.102 g, 69%).

Workup

  1. customdescribed in Example 1 (reaction time: 2 days)
  2. customThe crude obtained
  3. customwas triturated with ether
  4. filtrationfiltrated

Sources & evidence

ORD record
ord-1f68c221155c45488ee5089b71d9cbe9
Source dataset
uspto-grants-2012_05
Patent number
US08178679B2

Reaction notes

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