反应详情

A solution of Intermediate 47 (3.89 g, 17.49 mmol) in anhydrous tetrahydrofuran (5 mL) was slowly added under argon at 0° C. to a solution of lithium aluminium hydride (0.74 g, 19.5 mmol) in tetrahydrofuran (22 mL). The resulting mixture was stirred at room temperature for 5 hours. Then water (20 mL), sodium hydroxide 4N (20 mL) and finally water again (40 mL) were added into the solution at 0° C. The mixture was stirred for some minutes and the resulting salts were filtered through a pad of Celite®. The solvent was removed under reduced pressure and the title compound was obtained as a colourless solid (3.3 g, 97%) and used in the next step without further purification.

1. stirringThe mixture was stirred for some minutes
2. filtrationthe resulting salts were filtered through a pad of Celite®
3. customThe solvent was removed under reduced pressure