HCID 86649165, compound → HCID 67520886, compound

HRID 1925517Notes

Reaction equation

HRID 1925517 reaction equation
[C:1]12([CH2:11][CH2:12][O:13][C:14]3[CH:15]=[C:16]([CH2:20][C@H:21]([NH:23]C(=O)OC(C)(C)C)[CH3:22])[CH:17]=[CH:18][CH:19]=3)[CH2:10][CH:5]3[CH2:6][CH:7]([CH2:9][CH:3]([CH2:4]3)[CH2:2]1)[CH2:8]2>Cl>[C:1]12([CH2:11][CH2:12][O:13][C:14]3[CH:15]=[C:16]([CH2:20][C@H:21]([NH2:23])[CH3:22])[CH:17]=[CH:18][CH:19]=3)[CH2:10][CH:5]3[CH2:6][CH:7]([CH2:9][CH:3]([CH2:4]3)[CH2:2]1)[CH2:8]2

Participants

3

Reactant 1

HCID 86649165HCID 86649165, compound

Product 1

HCID 67520886HCID 67520886, compound

Reagents, catalysts & solvents 1

HCID 313Hydrochloric AcidSolvent

Procedure

Obtained from Intermediate 65 (5.8 g, 14 mmol) and hydrogen chloride (4M in dioxane, 20 mL) by the same procedure described in Intermediate 8. The crude obtained was purified by column chromatography with silica gel, eluting with methylen chloride/methanol/ammonium (40:4:0.2) and the title compound was obtained (2.5 g, 58%). MS (M+): 314.

Workup

  1. customThe crude obtained
  2. customwas purified by column chromatography with silica gel
  3. washeluting with methylen chloride/methanol/ammonium (40:4:0.2)

Sources & evidence

ORD record
ord-185f755c998e4390a8025f7fafc450d7
Source dataset
uspto-grants-2012_05
Patent number
US08178679B2

Reaction notes

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