反应详情

To a solution of Intermediate 71 (6.4 g, 31.07 mmol) in methanol (100 mL) was added ammonium formiate (7.8 g, 124.33 mmol), then under argon was added palladium on charcoal (0.6 g, 10%). The reaction mixture was stirred at room temperature for 3 hours. The catalyst was filtered through Celite® and the solvent removed under reduced pressure. The crude was treated with water and ethyl acetate, and the organic layer was extracted and the solvent was removed under reduced pressure. The title compound was obtained as an colourless iol (6.2 g, 95%).

1. filtrationThe catalyst was filtered through Celite®
2. customthe solvent removed under reduced pressure
3. additionThe crude was treated with water and ethyl acetate
4. extractionthe organic layer was extracted
5. customthe solvent was removed under reduced pressure