Hydroxyamine hydrochloride → 5-(6-fluoro-1H-benzimidazol-2-yl)pyrrolo[1,2-a]indol-9-one oxime

Participants

Reaction Steps

In a 20 ml round-bottomed flask, a mixture of 60 mg of 5-(6-fluoro-1H-benzimidazol-2-yl)pyrrolo[1,2-a]indol-9-one obtained according to the preceding stage and 42 mg of hydroxylamine hydrochloride in 5 ml of pyridine is brought to reflux for 6 hours. The reaction medium is evaporated to dryness under vacuum and the residue taken up with 25 ml of a saturated solution of sodium bicarbonate is extracted with 3 times 25 ml of ethyl acetate. The combined organic phases are washed with 25 ml of a saturated solution of sodium chloride, dried over magnesium sulphate, and evaporated to dryness under vacuum. 97 mg of 5-(6-fluoro-1H-benzimidazol-2-yl)pyrrolo[1,2-a]indol-9-one oxime are obtained in the form of a yellowish oil, the characteristics of which are the following:

Provenance & Evidence