反应详情

In a 20 ml round-bottomed flask, a mixture of 60 mg of 5-(6-fluoro-1H-benzimidazol-2-yl)pyrrolo[1,2-a]indol-9-one obtained according to the preceding stage and 42 mg of hydroxylamine hydrochloride in 5 ml of pyridine is brought to reflux for 6 hours. The reaction medium is evaporated to dryness under vacuum and the residue taken up with 25 ml of a saturated solution of sodium bicarbonate is extracted with 3 times 25 ml of ethyl acetate. The combined organic phases are washed with 25 ml of a saturated solution of sodium chloride, dried over magnesium sulphate, and evaporated to dryness under vacuum. 97 mg of 5-(6-fluoro-1H-benzimidazol-2-yl)pyrrolo[1,2-a]indol-9-one oxime are obtained in the form of a yellowish oil, the characteristics of which are the following:

1. customobtained
2. temperatureto reflux for 6 hours
3. customThe reaction medium is evaporated to dryness under vacuum
4. extractionis extracted with 3 times 25 ml of ethyl acetate
5. washThe combined organic phases are washed with 25 ml of a saturated solution of sodium chloride
6. dry with materialdried over magnesium sulphate
7. customevaporated to dryness under vacuum