Ethyl Acetate → HCID 59718775, compound

HRID 1925629Notes

Reaction equation

HRID 1925629 reaction equation
C(OCC)(=O)C.[C:7]([O:11][C:12]([NH:14][C:15]1([CH:21]=[CH:22][C:23]([O:25][CH2:26][CH3:27])=[O:24])[CH2:20][CH2:19][O:18][CH2:17][CH2:16]1)=[O:13])([CH3:10])([CH3:9])[CH3:8].[H][H]>[C].[Pd].CO>[C:7]([O:11][C:12]([NH:14][C:15]1([CH2:21][CH2:22][C:23]([O:25][CH2:26][CH3:27])=[O:24])[CH2:20][CH2:19][O:18][CH2:17][CH2:16]1)=[O:13])([CH3:10])([CH3:9])[CH3:8]

Participants

6

Reactant 3

HCID 8857Ethyl AcetateHCID 59718868HCID 59718868, compoundHCID 178418361HCID 178418361, compound

Product 1

HCID 59718775HCID 59718775, compound

Reagents, catalysts & solvents 2

HCID 178418390HCID 178418390, compoundCatalystHCID 887MethanolSolvent

Procedure

In the ethyl acetate (30 mL) and methanol (12 mL) mixed solution of ethyl 3-(4-t-butoxycarbonylamino-tetrahydro-pyran-4-yl)-acrylate which had been obtained in 3), 5% palladium carbon catalyst was added at room temperature. The reaction mixture was stirred under the hydrogen gas stream at room temperature for 75 minutes. The palladium catalyst was removed by filtration with Celite, and the filtrate was concentrated and dried up to give colorless oily matter (2.69 g).

Workup

  1. additionwas added at room temperature
  2. customThe palladium catalyst was removed by filtration with Celite
  3. concentrationthe filtrate was concentrated
  4. customdried up
  5. customto give colorless oily matter (2.69 g)

Sources & evidence

ORD record
ord-e018732a37f542388f082cc208f57599
Source dataset
uspto-grants-2012_05
Patent number
US08178681B2

Reaction notes

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