HCID 59718812, compound → Methyl 1-amino-4-fluorocyclohexanecarboxylate

HRID 1925633Notes

Reaction equation

HRID 1925633 reaction equation
[NH2:1][C:2]1([C:9]([O:11][CH3:12])=[O:10])[CH2:7][CH2:6][C:5]([F:8])=[CH:4][CH2:3]1.[H][H]>CO.C(OCC)(=O)C.[C].[Pd]>[NH2:1][C:2]1([C:9]([O:11][CH3:12])=[O:10])[CH2:7][CH2:6][CH:5]([F:8])[CH2:4][CH2:3]1

Participants

6

Reactant 2

HCID 59718812HCID 59718812, compoundHCID 178418361HCID 178418361, compound

Product 1

HCID 59718884Methyl 1-amino-4-fluorocyclohexanecarboxylate

Reagents, catalysts & solvents 3

HCID 178418390HCID 178418390, compoundCatalystHCID 887MethanolSolventHCID 8857Ethyl AcetateSolvent

Procedure

Methyl 1-amino-4-fluoro-3-cyclohexenecarboxylate (52 mg) was dissolved in the mixed solvents of methanol (2 mL) and ethyl acetate (2 mL), and 10% palladium-carbon (35 mg) was added and hydrogen gas was introduced for 14 hours. The insoluble matter was filtered and the solvent was removed by distillation under reduced pressure, and a mixture of the desired matter (BB09, 38 mg) was obtained.

Workup

  1. additionwas added
  2. filtrationThe insoluble matter was filtered
  3. customthe solvent was removed by distillation under reduced pressure
  4. additiona mixture of the desired matter (BB09, 38 mg)
  5. customwas obtained

Sources & evidence

ORD record
ord-03d5285b44d94719ac6091ea37751ad8
Source dataset
uspto-grants-2012_05
Patent number
US08178681B2

Reaction notes

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