Ethylamine → L-Theanine

Participants

Reaction Conditions

Reaction Steps

First, 5.0 g (31 mmol) of L-glutamic acid-γ-methyl ester was suspended in 15 mL of methanol. To this, 3.4 g (34 mmol) of acetylacetone and 5.0 g of anhydrous sodium sulfate were added. The mixture was heated at 60° C. for 6 hours. Subsequently, sodium sulfate was filtrated off. To the filtrate, 20 g (310 mmol) of 70% ethylamine was added and the same procedure as in Example 1 was performed to obtain 2.0 g of theanine (yield: 37.0%).

Provenance & Evidence