Calcium Chloride → HCID 28401833, compound

HRID 1925934Notes

Reaction equation

HRID 1925934 reaction equation
[Cl:1][C:2]1[CH:16]=[C:15]([N+:17]([O-])=O)[CH:14]=[CH:13][C:3]=1[O:4][C:5]1[CH:6]=[C:7]([CH:10]=[CH:11][CH:12]=1)[C:8]#[N:9].[Cl-].[Ca+2].[Cl-]>C(O)C.O>[NH2:17][C:15]1[CH:14]=[CH:13][C:3]([O:4][C:5]2[CH:6]=[C:7]([CH:10]=[CH:11][CH:12]=2)[C:8]#[N:9])=[C:2]([Cl:1])[CH:16]=1

Participants

4

Reactant 2

HCID 5284359Calcium ChlorideHCID 9194887HCID 9194887, compound

Product 1

HCID 28401833HCID 28401833, compound

Reagents, catalysts & solvents 1

HCID 19096565Water ethanolSolvent

Conditions

Temperature
100 °C

Procedure

To a solution of 3-(2-chloro-4-nitrophenoxy)benzonitrile (2.0 g) in ethanol/water (9:1, 40 mL) was added calcium chloride (90%, 449 mg), and the mixture was stirred at 100° C. for 10 min. Reduced iron (90%, 2.7 g) was added at room temperature, and the mixture was stirred at 100° C. for 5 hrs.

Workup

  1. stirringthe mixture was stirred at 100° C. for 5 hrs

Sources & evidence

ORD record
ord-4031c09e9cbc4a699fcbbc6c4893225f
Source dataset
uspto-grants-2012_05
Patent number
US08178543B2

Reaction notes

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