Hydrochloric Acid → HCID 57597313, compound

HRID 1926005Notes

Reaction equation

HRID 1926005 reaction equation
[N:1]1[C:6]2[CH:7]=[CH:8][NH:9][C:5]=2[C:4]([NH:10][C:11]2[CH:12]=[C:13]([CH:19]=[CH:20][CH:21]=2)[C:14]([O:16]CC)=[O:15])=[N:3][CH:2]=1.[OH-].[Na+].Cl>CO>[N:1]1[C:6]2[CH:7]=[CH:8][NH:9][C:5]=2[C:4]([NH:10][C:11]2[CH:12]=[C:13]([CH:19]=[CH:20][CH:21]=2)[C:14]([OH:16])=[O:15])=[N:3][CH:2]=1

Participants

5

Reactant 3

HCID 313Hydrochloric AcidHCID 14798Sodium HydroxideHCID 57597372HCID 57597372, compound

Product 1

HCID 57597313HCID 57597313, compoundYield 102.7%

Reagents, catalysts & solvents 1

HCID 887MethanolSolvent2×

Procedure

A mixture of ethyl 3-(5H-pyrrolo[3,2-d]pyrimidin-4-ylamino)benzoate (3.34 g), 1N aqueous sodium hydroxide solution (25 mL) and methanol (50 mL) was stirred overnight at room temperature. To the reaction mixture was added 1N hydrochloric acid (25 mL), and methanol was evaporated under reduced pressure. The precipitated crystals were collected by filtration and washed with water to give the title compound (3.09 g) as a pale-brown powder.

Workup

  1. customwas evaporated under reduced pressure
  2. filtrationThe precipitated crystals were collected by filtration
  3. washwashed with water

Sources & evidence

ORD record
ord-5db86716f8c3433fa742a4ef40e0d5af
Source dataset
uspto-grants-2012_05
Patent number
US08178543B2

Reaction notes

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