反应详情

To a solution of 3-chloro-4-{4-[3-(1H-imidazol-1-yl)propyl]phenoxy}nitrobenzene (669 mg) in methanol (7 mL) was added 5% Pt/C (140 mg), and the mixture was stirred under hydrogen atmosphere at room temperature for 16 hrs. 5% Pt/C was filtered off and the filtrate was concentrated. The residue was purified by basic silica gel column chromatography (eluent, ethyl acetate:hexane=80:20→100:0) and further washed with diethyl ether and hexane to give the title compound (277 mg) as a powder.

1. filtration5% Pt/C was filtered off
2. concentrationthe filtrate was concentrated
3. customThe residue was purified by basic silica gel column chromatography (eluent, ethyl acetate:hexane=80:20→100:0)
4. washfurther washed with diethyl ether and hexane