4-Chlorobenzylamine → HCID 67521395, compound

HRID 1926294Notes

Reaction equation

HRID 1926294 reaction equation
[CH3:1][O:2][CH:3]([O:8][CH3:9])[C:4](OC)=[O:5].[Cl:10][C:11]1[CH:18]=[CH:17][C:14]([CH2:15][NH2:16])=[CH:13][CH:12]=1>>[Cl:10][C:11]1[CH:18]=[CH:17][C:14]([CH2:15][NH:16][C:4](=[O:5])[CH:3]([O:8][CH3:9])[O:2][CH3:1])=[CH:13][CH:12]=1

Participants

3

Reactant 2

HCID 660364-ChlorobenzylamineHCID 66647Acetic acid, 2,2-dimethoxy-, methyl ester

Product 1

HCID 67521395HCID 67521395, compound

Conditions

Temperature
50 °C

Procedure

Into a vial was added methyl dimethoxyacetate (0.98 g, 7.3 mmol) and 4-chlorobenzylamine (1.0 g, 7.3 mmol), this mixture was stirred at 50° C. for 2 d. The product was recrystallized from Heptane to yield the desired product as an oil that solidified over time. MS (ES+): m/z=244.09/246.05 [MH+]. HPLC: tR=2.80 min (ZQ2, polar—5 min).

Workup

  1. customThe product was recrystallized from Heptane

Sources & evidence

ORD record
ord-cd8ccc7957af4ffb874569d854c7f9c6
Source dataset
uspto-grants-2012_05
Patent number
US08178668B2

Reaction notes

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