HuagongsheHuagongshe Chemistry Print Report · For research reference only
Hydrochloric Acid → 4-[6-Amino-5-(1,3-benzothiazol-2-yl)pyridin-3-yl]phenoxyacetic acid
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Hydrochloric Acid | HCID 313 | — |
| Reactant | Sodium Hydroxide | HCID 14798 | — |
| Reactant | Ethyl 4-[6-amino-5-(1,3-benzothiazol-2-yl)pyridin-3-yl]phenoxyacetate | HCID 67520764 | — |
| Solvent | Ethanol | HCID 702 | — |
| Product | 4-[6-Amino-5-(1,3-benzothiazol-2-yl)pyridin-3-yl]phenoxyacetic acid | HCID 67520876 | — |
Reaction Steps
To a suspension of ethyl 4-[6-amino-5-(1,3-benzothiazol-2-yl)pyridin-3-yl]phenoxyacetate (132 mg, 0.330 mmol) in EtOH (2.0 mL) was added 3M aqueous NaOH (0.50 mL, 1.5 mmol). Then, the mixture was acidified to pH=2 with 1M aq. HCl. Vacuum filtration afforded the title compound as a yellow solid. MS (ES+): m/z=506.88 (100) [MH+]. HPLC: tR=3.14 min (ZQ3, polar—5 min).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08178668B2 |
| Source dataset | uspto-grants-2012_05 |
| ORD ID | ord-4248f6e0300342a3ac1d33fbea0aa561 |
| Source note | uspto-grants-2012_05 |