2,5-Dichloro-1,3-benzothiazole → 2-Chloro-7-methyl-1,3-benzothiazole

HRID 1926396Notes

Reaction equation

HRID 1926396 reaction equation
F[C:2]1[C:8]([CH3:9])=[CH:7][CH:6]=[CH:5][C:3]=1[NH2:4].SC1SC2C(C)=CC=CC=2N=1.[Cl:21][C:22]1[S:23]C2C=CC(Cl)=CC=2N=1>>[Cl:21][C:22]1[S:23][C:2]2[C:8]([CH3:9])=[CH:7][CH:6]=[CH:5][C:3]=2[N:4]=1

Participants

4

Reactant 3

HCID 133148162,5-Dichloro-1,3-benzothiazoleHCID 227346232-Fluoro-3-methylanilineHCID 178424007HCID 178424007, compound

Product 1

HCID 552764852-Chloro-7-methyl-1,3-benzothiazole

Conditions

Temperature
180 °C

Procedure

The title compound was prepared from 2-fluoro-3-methylaniline via 2-mercapto-7-methyl-1,3-benzothiazole as described for 2,5-dichloro-1,3-benzothiazole except that in the first step the reaction mixture was heated to 180° C. for 24 h in a sealed tube.

Sources & evidence

ORD record
ord-485efb7d20e24fa096649e1404ecc564
Source dataset
uspto-grants-2012_05
Patent number
US08178668B2

Reaction notes

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