2-Bromo-3-methoxyaniline → 2-Chloro-7-methoxybenzo[d]thiazole

HRID 1926398Notes

Reaction equation

HRID 1926398 reaction equation
Br[C:2]1[C:8]([O:9][CH3:10])=[CH:7][CH:6]=[CH:5][C:3]=1[NH2:4].SC1SC2C(OC)=CC=CC=2N=1.[Cl:23][C:24]1[S:25]C2C=CC(Cl)=CC=2N=1>>[Cl:23][C:24]1[S:25][C:2]2[C:8]([O:9][CH3:10])=[CH:7][CH:6]=[CH:5][C:3]=2[N:4]=1

Participants

4

Reactant 3

HCID 109105752-Bromo-3-methoxyanilineHCID 133148162,5-Dichloro-1,3-benzothiazoleHCID 178489024HCID 178489024, compound

Product 1

HCID 552765892-Chloro-7-methoxybenzo[d]thiazole

Conditions

Temperature
120 °C

Procedure

The title compound was prepared from 2-bromo-3-methoxyaniline via 2-mercapto-7-methoxy-1,3-benzothiazole as described for 2,5-dichloro-1,3-benzothiazole except that in the first step the reaction mixture was heated to 120° C. for 10 h.

Sources & evidence

ORD record
ord-d3481608d2774da4a86698670aa7a252
Source dataset
uspto-grants-2012_05
Patent number
US08178668B2

Reaction notes

Loading…