2-Chloro-6-(trifluoromethoxy)-1,3-benzothiazole → 5-(1-Piperidin-4-yl-1H-pyrazol-4-yl)-3-(6-trifluoromethoxybenzothiazol-2-yl)-pyridin-2-ylamine

HRID 1926401Notes

Reaction equation

HRID 1926401 reaction equation
[NH:1]1[CH2:6][CH2:5][CH:4]([N:7]2[CH:11]=[C:10]([C:12]3[CH:13]=[C:14]([C:19]4[S:20][C:21]5[CH:27]=[CH:26][CH:25]=[C:24](C(F)(F)F)[C:22]=5[N:23]=4)[C:15]([NH2:18])=[N:16][CH:17]=3)[CH:9]=[N:8]2)[CH2:3][CH2:2]1.ClC1SC2C=C([O:42][C:43]([F:46])([F:45])[F:44])C=CC=2N=1>>[NH:1]1[CH2:2][CH2:3][CH:4]([N:7]2[CH:11]=[C:10]([C:12]3[CH:13]=[C:14]([C:19]4[S:20][C:21]5[CH:27]=[C:26]([O:42][C:43]([F:46])([F:45])[F:44])[CH:25]=[CH:24][C:22]=5[N:23]=4)[C:15]([NH2:18])=[N:16][CH:17]=3)[CH:9]=[N:8]2)[CH2:5][CH2:6]1

Participants

3

Reactant 2

HCID 100379242-Chloro-6-(trifluoromethoxy)-1,3-benzothiazoleHCID 675208855-(1-Piperidin-4-yl-1H-pyrazol-4-yl)-3-(4-trifluoromethylbenzothiazol-2-yl)-pyridin-2-ylamine

Product 1

HCID 675212295-(1-Piperidin-4-yl-1H-pyrazol-4-yl)-3-(6-trifluoromethoxybenzothiazol-2-yl)-pyridin-2-ylamine

Procedure

Following the procedure for 5-(1-piperidin-4-yl-1H-pyrazol-4-yl)-3-(4-trifluoromethylbenzothiazol-2-yl)-pyridin-2-ylamine, but using 2-chloro-6-trifluoromethoxy-1,3-benzothiazole, the title compound was obtained as yellow solid. MS (ES+): m/z=461.08 [MH+].

Sources & evidence

ORD record
ord-de623ccfc2f746f9997bbfc49ec74e6f
Source dataset
uspto-grants-2012_05
Patent number
US08178668B2

Reaction notes

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