2-Bromo-4-(trifluoromethoxy)aniline → 2-Chloro-6-(trifluoromethoxy)-1,3-benzothiazole

HRID 1926402Notes

Reaction equation

Br[C:2]1[CH:8]=[C:7]([O:9][C:10]([F:13])([F:12])[F:11])[CH:6]=[CH:5][C:3]=1[NH2:4].SC1SC2C=C(OC(F)(F)F)C=CC=2N=1.[Cl:29][C:30]1[S:31]C2C=CC(Cl)=CC=2N=1>>[Cl:29][C:30]1[S:31][C:2]2[CH:8]=[C:7]([O:9][C:10]([F:13])([F:12])[F:11])[CH:6]=[CH:5][C:3]=2[N:4]=1

Participants

Reactant 3

HCID 6882962-Bromo-4-(trifluoromethoxy)aniline

HCID 133148162,5-Dichloro-1,3-benzothiazole

HCID 178506356HCID 178506356, compound

Product 1

HCID 100379242-Chloro-6-(trifluoromethoxy)-1,3-benzothiazole

Conditions

Temperature: 150 °C

Procedure

The title compound was prepared from 2-bromo-4-trifluoromethoxyaniline via 2-mercapto-6-trifluoromethoxy-1,3-benzothiazole as described for 2,5-dichloro-1,3-benzothiazole except that in the first step the reaction mixture was heated to 150° C. for 16 h.

Sources & evidence

ORD record: ord-6f739f5f07154fc5a229c561525adc2c
Source dataset: uspto-grants-2012_05
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US08178668B2

Reaction notes

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