2-Chlorobenzo[d]thiazole-5-carbonitrile → 2-[2-Amino-5-(1-piperidin-4-yl-1H-pyrazol-4-yl)-pyridin-3-yl]-benzothiazole-5-carbonitrile

HRID 1926403Notes

Reaction equation

HRID 1926403 reaction equation
[NH:1]1[CH2:6][CH2:5][CH:4]([N:7]2[CH:11]=[C:10]([C:12]3[CH:13]=[C:14]([C:19]4[S:20][C:21]5[CH:27]=[CH:26][CH:25]=[C:24](C(F)(F)F)[C:22]=5[N:23]=4)[C:15]([NH2:18])=[N:16][CH:17]=3)[CH:9]=[N:8]2)[CH2:3][CH2:2]1.Cl[C:33]1SC2C=CC(C#N)=CC=2[N:37]=1>>[NH2:18][C:15]1[C:14]([C:19]2[S:20][C:21]3[CH:27]=[CH:26][C:25]([C:33]#[N:37])=[CH:24][C:22]=3[N:23]=2)=[CH:13][C:12]([C:10]2[CH:9]=[N:8][N:7]([CH:4]3[CH2:3][CH2:2][NH:1][CH2:6][CH2:5]3)[CH:11]=2)=[CH:17][N:16]=1

Participants

3

Reactant 2

HCID 219856792-Chlorobenzo[d]thiazole-5-carbonitrileHCID 675208855-(1-Piperidin-4-yl-1H-pyrazol-4-yl)-3-(4-trifluoromethylbenzothiazol-2-yl)-pyridin-2-ylamine

Product 1

HCID 441589352-[2-Amino-5-(1-piperidin-4-yl-1H-pyrazol-4-yl)-pyridin-3-yl]-benzothiazole-5-carbonitrile

Procedure

Following the procedure for 5-(1-piperidin-4-yl-1H-pyrazol-4-yl)-3-(4-trifluoromethylbenzothiazol-2-yl)-pyridin-2-ylamine, but using 2-chloro-1,3-benzothiazole-5-carbonitrile, the title compound was obtained as yellow solid. MS (ES+): m/z=402.13 [MH+].

Sources & evidence

ORD record
ord-c0b1e5dd72e547f290c16d3afdeaefc1
Source dataset
uspto-grants-2012_05
Patent number
US08178668B2

Reaction notes

Loading…