2,3-Difluoroaniline → 2-Iodo-5-methylbenzo[d]thiazole

HRID 1926416Notes

Reaction equation

HRID 1926416 reaction equation
F[C:2]1[C:10]2[S:9][C:8]([I:11])=[N:7][C:6]=2[CH:5]=[CH:4][CH:3]=1.F[C:13]1C(F)=CC=CC=1N.FC1C=CC(C)=CC=1N>>[I:11][C:8]1[S:9][C:10]2[CH:2]=[CH:3][C:4]([CH3:13])=[CH:5][C:6]=2[N:7]=1

Participants

4

Reactant 3

HCID 782782,3-DifluoroanilineHCID 2629702-Fluoro-5-methylanilineHCID 675211807-Fluoro-2-iodobenzo[d]thiazole

Product 1

HCID 675211012-Iodo-5-methylbenzo[d]thiazole

Procedure

The title compound was prepared following the route for 7-fluoro-2-iodo-1,3-benzothiazole from 2,3-difluoroaniline, starting from 2-fluoro-5-methylaniline and conducting the first step at 180° C. for 48 h in a sealed tube.

Workup

  1. customat 180° C.
  2. customfor 48 h

Sources & evidence

ORD record
ord-ad3a3a295ccf4c3587269cda83d26021
Source dataset
uspto-grants-2012_05
Patent number
US08178668B2

Reaction notes

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