2,3-Difluoroaniline → 7-Bromo-2-iodobenzothiazole

HRID 1926418Notes

Reaction equation

HRID 1926418 reaction equation
F[C:2]1[C:10]2[S:9][C:8]([I:11])=[N:7][C:6]=2[CH:5]=[CH:4][CH:3]=1.FC1C(F)=CC=CC=1N.[Br:21]C1C(Br)=CC=CC=1N>>[Br:21][C:2]1[C:10]2[S:9][C:8]([I:11])=[N:7][C:6]=2[CH:5]=[CH:4][CH:3]=1

Participants

4

Reactant 3

HCID 782782,3-DifluoroanilineHCID 155799982,3-DibromobenzenamineHCID 675211807-Fluoro-2-iodobenzo[d]thiazole

Product 1

HCID 675212127-Bromo-2-iodobenzothiazole

Procedure

The title compound was prepared following the route for 7-fluoro-2-iodo-1,3-benzothiazole from 2,3-difluoroaniline, starting from 2,3-dibromoaniline (prepared according to J. Org. Chem. 1990, 55(9), 2739) and conducting the first step at 95° C. for 4 h.

Workup

  1. customat 95° C.
  2. customfor 4 h.

Sources & evidence

ORD record
ord-a30deaeee92c4c7b8ce72a84d935e574
Source dataset
uspto-grants-2012_05
Patent number
US08178668B2

Reaction notes

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