4-Bromo-1,3-benzothiazol-2-amine → 2-Aminobenzo[d]thiazole-4-carbonitrile

HRID 1926436Notes

Reaction equation

HRID 1926436 reaction equation
[NH2:1][C:2]1[S:3][C:4]2[CH:10]=[CH:9][CH:8]=[C:7](Br)[C:5]=2[N:6]=1.[C:12]([Cu])#[N:13]>CN(C=O)C>[NH2:1][C:2]1[S:3][C:4]2[C:5](=[C:7]([C:12]#[N:13])[CH:8]=[CH:9][CH:10]=2)[N:6]=1

Participants

4

Reactant 2

HCID 20498884-Bromo-1,3-benzothiazol-2-amineHCID 178418546HCID 178418546, compound

Product 1

HCID 221525632-Aminobenzo[d]thiazole-4-carbonitrile

Reagents, catalysts & solvents 1

HCID 6228DimethylformamideSolvent

Procedure

The title compound was prepared from 2-amino-4-bromo-1,3-benzothiazole by heating with CuCN (1.0 eq.) in DMF at 160° C. for 12 h.

Sources & evidence

ORD record
ord-32dc9fde2c84460f8840becf468d7d1e
Source dataset
uspto-grants-2012_05
Patent number
US08178668B2

Reaction notes

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