HCID 67520443, compound → HCID 67521430, compound

HRID 1926441Notes

Reaction equation

HRID 1926441 reaction equation
F[C:2]1[C:10]2[S:9][C:8]([C:11]3[C:12]([NH2:28])=[N:13][CH:14]=[C:15]([C:17]4[CH:18]=[N:19][N:20]([CH:22]5[CH2:27][CH2:26][NH:25][CH2:24][CH2:23]5)[CH:21]=4)[CH:16]=3)=[N:7][C:6]=2[C:5]([C:29](F)(F)F)=[CH:4][CH:3]=1.IC1SC2CCCCCC=2N=1>>[NH:25]1[CH2:26][CH2:27][CH:22]([N:20]2[CH:21]=[C:17]([C:15]3[CH:16]=[C:11]([C:8]4[S:9][C:10]5[CH2:2][CH2:3][CH2:4][CH2:5][CH2:29][C:6]=5[N:7]=4)[C:12]([NH2:28])=[N:13][CH:14]=3)[CH:18]=[N:19]2)[CH2:23][CH2:24]1

Participants

3

Reactant 2

HCID 67520443HCID 67520443, compoundHCID 67520656HCID 67520656, compound

Product 1

HCID 67521430HCID 67521430, compound

Procedure

Following the procedure for 3-(7-fluoro-4-trifluoromethylbenzothiazol-2-yl)-5-(1-piperidin-4-yl-1H-pyrazol-4-yl)-pyridin-2-ylamine, using 2-iodo-5,6,7,8-tetrahydro-4H-cycloheptathiazole and conducting the Suzuki coupling at 55° C. for 3 h, the title compound was obtained as a yellow solid. MS (ES+): m/z=395.19 [MH+]. HPLC: tR=2.21 min (ZQ3, polar—5 min).

Workup

  1. customat 55° C.
  2. customfor 3 h

Sources & evidence

ORD record
ord-b26ca5833465494ba842ac7205ed9873
Source dataset
uspto-grants-2012_05
Patent number
US08178668B2

Reaction notes

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