反应详情

To a stirred solution of N-(5-nitro-2-methylpyrid-3-yl)-4-(pyrid-3-yl)-2-pyrimidinamine (18.0 g) and hydrazine hydrate (9 mL) in ethanol (180 mL) was added activated nickel (0. g). The mixture was refluxed for 3 hours, filtrated and the filtrate was concentrated in vacuo to give solid, which was put in the fridge (0° C.) overnight. The residue was filtrated off and the filtrate was concentrated in vacuo to give N-(5-amino-2-methylpyrid-3-yl)-4-(pyrid-3-yl)-2-pyrimidinamine (15 g).

1. temperatureThe mixture was refluxed for 3 hours
2. filtrationfiltrated
3. concentrationthe filtrate was concentrated in vacuo
4. customto give solid, which
5. customwas put in the fridge (0° C.) overnight
6. filtrationThe residue was filtrated off
7. concentrationthe filtrate was concentrated in vacuo