2,6-Dichloropyrazine → Tert-butyl 4-(6-chloropyrazin-2-ylamino)piperidine-1-carboxylate

HRID 1926640Notes

Reaction equation

HRID 1926640 reaction equation
Cl[C:2]1[CH:7]=[N:6][CH:5]=[C:4]([Cl:8])[N:3]=1.[NH2:9][CH:10]1[CH2:15][CH2:14][N:13]([C:16]([O:18][C:19]([CH3:22])([CH3:21])[CH3:20])=[O:17])[CH2:12][CH2:11]1.ClC1N=C(N2CCN(C(OC(C)(C)C)=O)CC2)C=NC=1>>[Cl:8][C:4]1[N:3]=[C:2]([NH:9][CH:10]2[CH2:11][CH2:12][N:13]([C:16]([O:18][C:19]([CH3:22])([CH3:21])[CH3:20])=[O:17])[CH2:14][CH2:15]2)[CH:7]=[N:6][CH:5]=1

Participants

4

Reactant 3

HCID 785042,6-DichloropyrazineHCID 12682914-Amino-1-Boc-piperidineHCID 18186946Tert-butyl 4-(6-chloropyrazin-2-YL)piperazine-1-carboxylate2×

Product 1

HCID 53486077Tert-butyl 4-(6-chloropyrazin-2-ylamino)piperidine-1-carboxylate

Procedure

tert-butyl 4-[(6-chloropyrazin-2-yl)amino]piperidine-1-carboxylate was prepared from 2,6-dichloropyrazine and tert-butyl 4-aminopiperidine-1-carboxylate using the conditions described for the preparation of tert-butyl 4-(6-chloropyrazin-2-yl)piperazine-1-carboxylate (Compound 1, Step 6). LRMS calculated for C14H21ClN4O2 [M+Na]+, 335.1; found 335.1.

Sources & evidence

ORD record
ord-07cb7c5c99f94fcdb58916bc500996b7
Source dataset
uspto-grants-2012_05
Patent number
US08183245B2

Reaction notes

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