HuagongsheHuagongshe Chemistry Print Report · For research reference only
2,6-Dichloropyrazine → Tert-butyl 4-(6-chloropyrazin-2-ylamino)piperidine-1-carboxylate
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 2,6-Dichloropyrazine | HCID 78504 | — |
| Reactant | 4-Amino-1-Boc-piperidine | HCID 1268291 | — |
| Reactant | Tert-butyl 4-(6-chloropyrazin-2-YL)piperazine-1-carboxylate | HCID 18186946 | — |
| Product | Tert-butyl 4-(6-chloropyrazin-2-ylamino)piperidine-1-carboxylate | HCID 53486077 | — |
Reaction Steps
tert-butyl 4-[(6-chloropyrazin-2-yl)amino]piperidine-1-carboxylate was prepared from 2,6-dichloropyrazine and tert-butyl 4-aminopiperidine-1-carboxylate using the conditions described for the preparation of tert-butyl 4-(6-chloropyrazin-2-yl)piperazine-1-carboxylate (Compound 1, Step 6). LRMS calculated for C14H21ClN4O2 [M+Na]+, 335.1; found 335.1.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08183245B2 |
| Source dataset | uspto-grants-2012_05 |
| ORD ID | ord-07cb7c5c99f94fcdb58916bc500996b7 |
| Source note | uspto-grants-2012_05 |