HuagongsheHuagongshe Chemistry Print Report · For research reference only
2,6-Dichloropyrazine → Tert-butyl cis-4-[(6-chloropyrazin-2-yl)oxy]-3-fluoropiperidine-1-carboxylate
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 2,6-Dichloropyrazine | HCID 78504 | — |
| Reactant | tert-Butyl 4-((6-chloropyrazin-2-yl)oxy)piperidine-1-carboxylate | HCID 21906088 | — |
| Reactant | tert-butyl (3R,4S)-3-fluoro-4-hydroxypiperidine-1-carboxylate | HCID 40152152 | — |
| Product | Tert-butyl cis-4-[(6-chloropyrazin-2-yl)oxy]-3-fluoropiperidine-1-carboxylate | HCID 86644306 | — |
Reaction Steps
tert-butyl cis-4-[(6-chloropyrazin-2-yl)oxy]-3-fluoropiperidine-1-carboxylate was prepared from 2,6-dichloropyrazine and tert-butyl cis-3-fluoro-4-hydroxypiperidine-1-carboxylate using the conditions described for the preparation of tert-butyl 4-[(6-chloropyrazin-2-yl)oxy]piperidine-1-carboxylate (Compound 1, Step 3). LRMS (ESI) calculated for C14H19ClFN3O3[M+Na]+, 354.1; found 354.1.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08183245B2 |
| Source dataset | uspto-grants-2012_05 |
| ORD ID | ord-60ef72da12bc4b66975c8c5c94f94d43 |
| Source note | uspto-grants-2012_05 |