Hydrochloric Acid → HCID 68930220, compound

HRID 1926682Notes

Reaction equation

[CH:1]1([CH:4]([C:20]2[CH:25]=[CH:24][CH:23]=[C:22]([C:26]([F:29])([F:28])[F:27])[CH:21]=2)[N:5]2[CH2:10][CH2:9][N:8]([CH2:11][C:12]([O:14]C(C)(C)C)=[O:13])[C@H:7]([CH3:19])[CH2:6]2)[CH2:3][CH2:2]1.[ClH:30]>>[ClH:30].[ClH:30].[CH:1]1([CH:4]([C:20]2[CH:25]=[CH:24][CH:23]=[C:22]([C:26]([F:28])([F:29])[F:27])[CH:21]=2)[N:5]2[CH2:10][CH2:9][N:8]([CH2:11][C:12]([OH:14])=[O:13])[C@H:7]([CH3:19])[CH2:6]2)[CH2:3][CH2:2]1

Participants

Reactant 2

HCID 313Hydrochloric Acid

HCID 68931842HCID 68931842, compound

Product 1

HCID 68930220HCID 68930220, compoundYield 79.6%

Conditions

Temperature: 50 °C

Procedure

To tert-butyl 2-((R)-4-(cyclopropyl(3-(trifluoromethyl)phenyl)methyl)-2-methylpiperazin-1-yl)acetate (350 mg, 0.849 mmol) in 150 mL flask was added 3 mL of 37% HCl and the resulting solution was stirred at 50° C. for 3 h. After HPLC-MS showed complete conversion, the solvent was evaporated to dryness under high vacuum to give 2-((R)-4-(cyclopropyl(3-(trifluoromethyl)phenyl)methyl)-2-methylpiperazin-1-yl)acetic acid dihydrochloride (290 mg, 79.6% yield) as a white solid. MS (ESI, pos. ion) m/z: 357 (M+1).

Workup

customthe solvent was evaporated to dryness under high vacuum

Sources & evidence

ORD record: ord-94128549b5d548bb935cc7539b8f1951
Source dataset: uspto-grants-2012_05
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US08183244B2

Reaction notes

Loading…