82420-39-1 → HCID 59627195, compound

HRID 1926698Notes

Reaction equation

Cl.[NH2:2][CH:3]([CH2:7][C:8]1[CH:13]=[C:12]([Cl:14])[CH:11]=[C:10]([CH3:15])[C:9]=1[N+:16]([O-:18])=O)[C:4](O)=[O:5].Cl.NC(CC1C=CC(Br)=CC=1[N+]([O-])=O)C(O)=O.C(NC(CC1C=C(Cl)C=C(C)C=1[N+]([O-])=O)(C(OCC)=O)C(OCC)=O)(=O)C>>[NH2:2][CH:3]1[CH2:7][C:8]2[C:9](=[C:10]([CH3:15])[CH:11]=[C:12]([Cl:14])[CH:13]=2)[N:16]([OH:18])[C:4]1=[O:5]

Participants

Reactant 3

HCID 1276138382420-39-1

HCID 59627070HCID 59627070, compound

HCID 131729729HCID 131729729, compound

Product 1

HCID 59627195HCID 59627195, compound

Procedure

2-Amino-3-(5-chloro-3-methyl-2-nitrophenyl)propanoic acid, hydrochloride salt (40) Following the procedure for the preparation of 2-amino-3-(4-bromo-2-nitrophenyl)propanoic acid, hydrochloride salt (25) in Example 5, diethyl acetamido(5-chloro-3-methyl-2-nitrobenzyl)malonate (39) was converted to the title product, which was obtained as a solid (assumed quantitative); LCMS m/z 259.0 (M+1).

Sources & evidence

ORD record: ord-5db988dd345d4d80bf8b1774ad127bc9
Source dataset: uspto-grants-2012_05
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US08183238B2

Reaction notes

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