HuagongsheHuagongshe Chemistry Print Report · For research reference only
Methylamine → N-Methyl-N-[(4-{[2-(trifluoromethyl)pyrimidin-5-yl]oxy}phenyl)methyl]amine
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Methylamine | HCID 6329 | — |
| Reactant | 4-{[2-(Trifluoromethyl)-5-pyrimidinyl]oxy}benzaldehyde | HCID 86623131 | — |
| Solvent | Ethanol | HCID 702 | — |
| Product | N-Methyl-N-[(4-{[2-(trifluoromethyl)pyrimidin-5-yl]oxy}phenyl)methyl]amine | HCID 67131360 | 95% |
Reaction Steps
4-{[2-(Trifluoromethyl)pyrimidin-5-yl]oxy}benzaldehyde was stirred with 33% methylamine in 95% ethanol (30 mL) at reflux for 1 hour and then concentrated. The residue was re-dissolved in 95% ethanol, 10% palladium/carbon was added, and the mixture was hydrogenated at room temperature under atmospheric pressure for 30 minutes. The reaction was performed on a 5.0 mmol scale with a yield of 95%.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08183251B2 |
| Source dataset | uspto-grants-2012_05 |
| ORD ID | ord-d96ceca2f1704177a97dbbdacbd3f42b |
| Source note | uspto-grants-2012_05 |