反应详情

4-{[2-(Trifluoromethyl)pyrimidin-5-yl]oxy}benzaldehyde was stirred with 33% methylamine in 95% ethanol (30 mL) at reflux for 1 hour and then concentrated. The residue was re-dissolved in 95% ethanol, 10% palladium/carbon was added, and the mixture was hydrogenated at room temperature under atmospheric pressure for 30 minutes. The reaction was performed on a 5.0 mmol scale with a yield of 95%.

1. temperatureat reflux for 1 hour
2. concentrationconcentrated
3. dissolutionThe residue was re-dissolved in 95% ethanol
4. addition10% palladium/carbon was added