HCID 86631464, compound → HCID 57743028, compound

HRID 1926740Notes

Reaction equation

HRID 1926740 reaction equation
Cl.[O:2]=[C:3]1[CH2:7][CH:6]([CH2:8][CH2:9][CH3:10])[CH2:5][N:4]1[CH2:11][C:12]1[N:16]([CH2:17][C:18]([O:20]CC)=[O:19])[CH:15]=[N:14][CH:13]=1>Cl>[O:2]=[C:3]1[CH2:7][CH:6]([CH2:8][CH2:9][CH3:10])[CH2:5][N:4]1[CH2:11][C:12]1[N:16]([CH2:17][C:18]([OH:20])=[O:19])[CH:15]=[N:14][CH:13]=1

Participants

3

Reactant 1

HCID 86631464HCID 86631464, compound

Product 1

HCID 57743028HCID 57743028, compound

Reagents, catalysts & solvents 1

HCID 313Hydrochloric AcidSolvent

Conditions

Temperature
40 °C

Procedure

In a 250 ml, three necked flask fitted with a magnetic stirrer, ethyl {5-[(2-oxo-4-propylpyrrolidin-1-yl)methyl]-1H-imidazol-1-yl}acetate hydrochloride x49 (5.19 g, 0.018 mol) is dissolved in 2M HCl (150 ml) and heated at 40° C. for 20 h. The reaction mixture is evaporated to dryness to afford the crude acid x50 (6.19 g) that is used as such in the next step.

Workup

  1. customIn a 250 ml, three necked flask fitted with a magnetic stirrer
  2. customThe reaction mixture is evaporated to dryness

Sources & evidence

ORD record
ord-11d352bbb72542229a204cb401cc2516
Source dataset
uspto-grants-2012_05
Patent number
US08183241B2

Reaction notes

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