Bromoacetic Acid → HCID 53629180, compound

HRID 1926819Notes

Reaction equation

HRID 1926819 reaction equation
[Cl:1][C:2]1[S:6][C:5]([NH2:7])=[N:4][CH:3]=1.[Br:8][CH2:9][C:10]([OH:12])=[O:11]>CCO>[BrH:8].[Cl:1][C:2]1[S:6][C:5](=[NH:7])[N:4]([CH2:9][C:10]([OH:12])=[O:11])[CH:3]=1

Participants

4

Reactant 2

HCID 6227Bromoacetic AcidHCID 389422-Amino-5-chlorothiazole

Product 1

HCID 53629180HCID 53629180, compoundYield 10%

Reagents, catalysts & solvents 1

HCID 702EthanolSolvent

Procedure

At room temperature, 5-chloro-1,3-thiazol-2-amine x170 (1.49 g, 11.03 mmol, 1 eq) is added to a well stirred solution of bromoacetic acid (1.68 g, 11.03 mmol, 1 eq) in EtOH (50 ml). The mixture is heated at reflux during 8 hours. After cooling, the resulting precipitate is filtrated dried under vacuum to yield 288 mg of (5-chloro-2-imino-1,3-thiazol-3(2H)-yl)acetic acid hydrobromide x171 as a white solid.

Workup

  1. temperatureThe mixture is heated
  2. temperatureat reflux during 8 hours
  3. temperatureAfter cooling
  4. filtrationthe resulting precipitate is filtrated
  5. customdried under vacuum

Sources & evidence

ORD record
ord-f11b7978223947c18385b90d549b68f2
Source dataset
uspto-grants-2012_05
Patent number
US08183241B2

Reaction notes

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