反应详情

Heat 80 g (378.7 mmol) 6-phenylfuro[2,3-d]pyrimidine-4-amine in 770 ml carbon tetrachloride to 60° C. Add 84.3 g (473.4 mmol) N-bromosuccinimide, and stir the mixture overnight under reflux. After cooling, filter, mix the filter cake successively with dichloromethane and acetonitrile, and filter again. Then dry the filter cake under vacuum. 86 g of the target product (78.2% of theor.) is obtained.

1. temperatureunder reflux
2. temperatureAfter cooling
3. filtrationfilter
4. additionmix the filter cake successively with dichloromethane and acetonitrile
5. filtrationfilter again
6. customThen dry the filter cake under vacuum