HuagongsheHuagongshe Chemistry Print Report · For research reference only
N-bromobutanimide → 5-Bromo-6-phenylfuro[2,3-d]pyrimidine-4-amine
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | N-bromobutanimide | HCID 67184 | — |
| Reactant | 6-Phenylfuro[2,3-d]pyrimidin-4-amine | HCID 696524 | — |
| Solvent | Carbon Tetrachloride | HCID 5943 | — |
| Product | 5-Bromo-6-phenylfuro[2,3-d]pyrimidine-4-amine | HCID 59427829 | 78.3% |
Reaction Steps
Heat 80 g (378.7 mmol) 6-phenylfuro[2,3-d]pyrimidine-4-amine in 770 ml carbon tetrachloride to 60° C. Add 84.3 g (473.4 mmol) N-bromosuccinimide, and stir the mixture overnight under reflux. After cooling, filter, mix the filter cake successively with dichloromethane and acetonitrile, and filter again. Then dry the filter cake under vacuum. 86 g of the target product (78.2% of theor.) is obtained.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08183246B2 |
| Source dataset | uspto-grants-2012_05 |
| ORD ID | ord-1f0721bbf63744c2b660b4df42dd83e4 |
| Source note | uspto-grants-2012_05 |