反应详情

Dissolve 25 mg (0.05 mmol) 6-{[6-(2-fluorophenyl)-5-(4-methoxyphenyl)furo[2,3-d]pyrimidin-4-yl]amino}hexanoic acid methyl ester in 1.0 ml dioxan and add 0.16 ml 1 N sodium hydroxide solution. Stir for 16 h at RT, then add 0.17 ml 1 N hydrochloric acid and then 2 ml water and 5 ml dichloromethane. Separate the organic phase, dry over sodium sulphate, filter, and concentrate by evaporation. 23 mg (92% of theor.) of the target compound is obtained.

1. customSeparate the organic phase
2. dry with materialdry over sodium sulphate
3. filtrationfilter
4. concentrationconcentrate by evaporation
5. custom23 mg (92% of theor.) of the target compound is obtained