反应详情

Add 0.5 ml 1 N sodium hydroxide solution to a solution of 45 mg (0.01 mmol) 6-{[6-(3-fluorophenyl)-5-(4-methoxyphenyl)furo[2,3-d]pyrimidin-4-yl]amino}hexanoic acid methyl ester in 2.5 ml dioxan, and stir for 16 h at RT. After adding 0.75 ml 1 N hydrochloric acid, concentrate the reaction solution by vacuum evaporation. Mix the residue with diethyl ether, filter, and dry under vacuum. 42 mg (93% of theor.) of the desired product is obtained.

1. concentrationconcentrate the reaction solution
2. customby vacuum evaporation
3. additionMix the residue with diethyl ether
4. filtrationfilter
5. customdry under vacuum